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Lithium orotate is lithium bound to orotic acid, which improves its bioavailability. It is thought that some of the nutritional benefits of lithium come from its ability to support the synthesis and recycling of inositol, a primary component of the phosphoinositol signaling pathway. Research also shows that lithium supports the health and function of the hippocampus.** The addition of vitamin B12 and trimethylglycine (TMG) to Lithium Synergy™ helps support healthy methylation pathways, and vitamin B12 is also needed for the synthesis of SAMe.
Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.
Lithium Synergy combines lithium orotate, known for its ability to help stabilize mood swings related to depression and other mood disorders, with vitamin B12 (methylcobalamin) and trimethylglycine to support healthy methylation pathways.
How does lithium orotate work?
Mood disorders are often due to inositol depletion. Lithium recycles and synthesizes inositol by inhibiting the IMPase enzyme. The phosphoinositol signaling pathway is involved in cell membrane signaling cascades. When salts of lithium are ingested, the lithium ions interact with several neurotransmitters and receptors in the central nervous system, resulting in decreased norepinephrine release and increased serotonin synthesis.
Why add vitamin B12 and TMG (trimethylglycine)?
Both vitamin B12 in the form of methylcobalamin and trimethylglycine can donate methyl groups to improve methylation; often a weakness in patients with depression and other disorders.
Observational studies have found that as many as 30% of patients hospitalized for depression are deficient in vitamin B12. The reasons for the relationship between vitamin B12 deficiency and depression may involve s-adenosylmethionine (SAMe). Vitamin B12 is required for the synthesis of SAMe, a methyl group donor essential for methylation reactions and subsequently the metabolism of neurotransmitters. SAMe deficiency has been related to depression; this hypothesis is supported by several studies that have shown supplementation with SAMe improves depressive symptoms.